Innovations in chemistry rely on the invention of new concepts, reactions and technologies that allow the straightforward elaboration of molecular complexity with tailor-made properties. In this regard, methods leading to heterocycles are essential since these small molecules constitute the core structure of numerous biologically active compounds of natural or synthetic origins. The STEELE project aims at unlocking the chemical synthesis of a class of heterocycles called indoles, with two desirable properties: the presence of emergent fluorinated substituents and of so-called stereogenic centers. STEELE gathers three research groups with complementary expertise in heterocyclic chemistry, fluorine chemistry and asymmetric synthesis. The project is supported by Eucor – The European Campus in the “Research and Innovation” category of the Seed Money scheme.